[Jun 24th 2020] LabMeeting: mCSM-membrane: predicting the effects of mutations on transmembrane proteins

Anna Visibelli (University of Siena) Jun 24, 2020 – 11:00 AM Conference Meeting Description Significant efforts have been invested into understanding and predicting the molecular consequences of mutations in protein coding regions, however nearly all approaches have been developed using globular, soluble proteins. These methods have been shown to poorly translate to studying the effects […]

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[Jun 17th 2020] LabMeeting: Analyzing and Improving the Image Quality of StyleGAN

Giorgio Ciano (University of Florence) Jun 17, 2020 – 11:00 AM Conference Meeting Description The style-based GAN architecture (StyleGAN) yields state-of-the-art results in data-driven unconditional generative image modeling. We expose and analyze several of its characteristic artifacts, and propose changes in both model architecture and training methods to address them. In particular, we redesign generator […]

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[Jun 3rd 2020] LabMeeting: Wave Propagation of Visual Stimuli in Focus of Attention

Lapo Faggi (University of Florence) Jun 3, 2020 – 11:00 AM Conference Meeting Description Fast reactions to changes in the surrounding visual environment require efficient attention mechanisms to reallocate computational resources to the most relevant locations in the visual field. While current computational models keep improving their predictive ability thanks to the increasing availability of […]

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[May 20th 2020] LabMeeting: Towards understanding glasses with graph neural networks

Niccolò Pancino May 20, 2020 – 11:00 AM Conference Meeting Description The glass transition is a reversible transition that occurs when an amorphous polymer material is heated or cooled in a particular temperature range. On cooling, the material becomes less flexible, like a glass, and on heating becomes soft. This characteristics dramatically affects the usefulness […]

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[May 6th 2020] LabMeeting: A workbench for the translational control of gene expression

Giorgia Giacomini May 6th, 2020 – 11:00 AM Conference Meeting Description Ribosome profiling (Ribo-seq profiling) is the most advanced tool to study the translational control of gene expression. Unfortunately, the resolution of this cutting edge technique is severely limited by a low signal to noise ratio. To tackle this issue, we introduce here a newly […]

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[Apr 29th 2020] LabMeeting: COVID-19 Italian and European pandemic: a SEIR model with undetected fraction and mobility-dependent transmission rate

Nicola Picchiotti Apr 29, 2020 – 11:00 AM Conference Meeting Description We propose a COVID-19 pandemic modelling, based on a SEIR compartmental framework, taking into account the heterogeneous fraction of undetected cases, the mobility variations along time and the adoption of personal protective measures. The model is experimentally validated across both Italian regions and several […]

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[Apr 22nd 2020] LabMeeting: A possible strategy to fight COVID-19:Interfering with spike glycoprotein trimerization.

Pietro Bongini (University of Florence) Apr 22, 2020 – 11:00 AM Conference Meeting Description The recent release of COVID-19 spike glycoprotein allows detailed analysis of the structural features that are required for stabilizing the infective form of its quaternary assembly. Trying to disassemble the trimeric structure of COVID-19 spike glycoprotein, we analyzed single protomer surfaces […]

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[Apr 15 2020] LabMeeting: On Mutual Information Maximization for Representation Learning

Matteo Tiezzi (University of Siena) Apr 15, 2020 – 11:00 AM Conference Meeting Description Many recent methods for unsupervised or self-supervised representation learning train feature extractors by maximizing an estimate of the mutual information (MI) between different views of the data. This comes with several immediate problems. For example, MI is notoriously hard to estimate, […]

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